Dr. Yousif Rojeab
Major curricular areas:
Pharmaceutical Sciences Module I
Pharmaceutical Sciences Module II
Pharmaceutical Compounding Laboratory
Pharmacokinetics (Non-Traditional Doctor of Pharmacy Program)
Miscellaneous lectures: Cardiovascular Module and Profession of Pharmacy 4
- Extensive knowledge and experience in the design and implementation of pharmacokinetic (PK) studies for i.v., i.m., p.o. and transdermal routes of administration in rat and mouse animal models.
- Significant knowledge in the theory and application of compartmental and non-compartmental models for PK data analysis.
- Detailed knowledge of PK modeling and statistical data analysis and reporting using WinNonlin, ADAPT II, Sigma Plot, SPSS, Minitab, Microsoft word, Excel and PowerPoint.
- Comprehensive knowledge of the theoretical and practical aspects of microdialysis as a technique for continuous sampling in PK studies.
- Working knowledge in population PK and PK/PD analyses.
- Tumor induction in the nude mouse animal model for the efficacy evaluation of anti-cancer chemotherapeutic agents.
- In-depth knowledge and experience in formulation and characterization of microemulsions and microemulsion-based gel (MBG) formulations.
- Significant knowledge and experience in HPLC method development and validation for aqueous as well as biological samples.
- Excellent ability in experimental design and data analysis.
- Significant knowledge in the regulatory aspects of drug development.
- Supervising experience in pharmaceutics research laboratory of several students including junior graduate students, Pharm D students, Pharm D/Ph.D. students.
- American Association for Cancer Research (AACR)
- American Association of Pharmaceutical scientists (AAPS)
- American Association of Colleges of Pharmacy (AACP)
- American Chinese Pharmaceutical Association (ACPA), President of the University of Houston Student Chapter: 2005-06.
- Sigma Xi Research Society
- Ph.D. in Pharmaceutics from the University of Houston, Houston, TX (2007)
- B.Sc. in Pharmacy with Excellent Rating from Jordan University of Science and Technology, Jordan (1999)
- Goel Academic Achievement Award / University of Houston, TX, 2004.
- Sigma Xi Research Award for the Poster Competition, University of Houston, TX, twice in 2004 and 2006.
- The Dean’s List for Excellence in Academic Performance, Jordan University of Science & Technology, three times in 1995, 1996 & 1999.
October 2007 - February 2008: Fasprin® Clinical Study, Ohio Northern University, Ada, OH:
- Participated* in the design, conduction, samples and data analyses of a clinical study aimed at characterizing the pharmacokinetics of aspirin and its hydrolysis product, salicylic acid, from Fasprin® (aspirin; 81 mg).
*Study was conducted in healthy volunteers. Research team consisted of three pharmacy
professors, four nursing professors, one physician and three Pharm D students.
Dissertation Title: “Microemulsion Formulations of CZ48, Lactone-Stabilized Camptothecin-C20-Propionate, for Transdermal Delivery”
May 2002 - May 2007: Dr. Diana S-L Chow’s laboratory, University of Houston;
- Developed and characterized a novel proto-type microemulsion formulation of CZ48 (pro-drug). The formulation was further optimized with the incorporation of a co-solvent, a solubilizer and a penetration enhancer.
- Conducted several PK studies for the simultaneous quantifications of CZ48 and CPT (active metabolite) after transdermal, i.v., i.m. and oral administrations in Swiss-Nude mice.
- Performed whole blood collection through either tail, retro-orbital or femoral veins following i.v., i.m. and oral administrations.
- Employed the microdialysis technique by subcutaneous and intra-vascular probe implantation for simultaneous quantifications of the pro-drug and active metabolite after topical application of CZ48-containing microemulsions on the abdominal skin of Swiss-Nude mice.
- Performed detailed PK analyses on the pro-drug and its active metabolite with both compartmental and non-compartmental models upon i.v., i.m. and oral administration using WinNonlin Professional version 3.2.
- Work resulted in five abstracts. Three presented at the Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS) in 2004, 2005 and 2006. The other two presented at the Annual Meeting of the American Association for Cancer Research (AACR) in 2004 and 2005. Manuscripts are currently in preparation.
August 2001 - December 2001: Laboratory rotation at under the supervision of Dr. Dong Liang, adjunct Faculty at University of Houston, Faculty at Texas Southern University;
- Learned the theory and techniques of small animal experimentation necessary for conducting PK studies such as animal handling, surgery, probe implantation and dosing.
- Conducted pre-formulation studies on Mebendazole for anti-neoplastic indications such as pH-solubility profiling, pH-stability, accelerated drug stability and partition coefficient evaluations.
- Work resulted in an abstract that was presented at the annual meeting of the American Association of Pharmaceutical Scientists (AAPS), Toronto, Canada, 2002.
1. Yousif Rojeab and David Kisor. Pharmacokinetic Analysis of Orally Administered Fasprin®, a Low-Dose Aspirin Formulation (manuscript: to be submitted to the American Journal of Health-System Pharmacy (AJHP)).
2. M.A. Tupps, K.E. Turkaly, Y. Rojeab, B.S. Martin, D.F. Kisor. “Pharmacokinetics of Low Dose ASA (Fasprin®). Poster to be presented at the Annual Meeting of the American Society of Health-System Pharmacists, Orlando, FL, December 2008.
3. Yousif Rojeab, Beppino C. Giovanella and Diana S-L. Chow. Enhanced Transdermal Delivery CZ48, Lactone-Stabilized Camptothecin-C20-Propionate, from Microemulsion Formulations, Through Excised Rat Skin, in Vitro (manuscript: to be submitted to the Journal of Pharmaceutical Sciences).
4. Yousif Rojeab, Beppino C. Giovanella and Diana S-L. Chow. “In Vitro and in Vivo Evaluations of Microemulsion Formulations of CZ48, Lactone-Stabilized Camptothecin-C20-Propionate, for Transdermal Delivery” Abstract submitted, Annual Meeting of the Controlled Release Society (CRS), Long Beach, CA, April 2007.
5. Yousif Rojeab, Beppino C. Giovanella and Diana S-L. Chow. “Comparative pharmacokinetics of microemulsion of CZ48, lactone-stabilized camptothecin-C20-propionate, from different routes of administration in nude mice” Abstract submitted, Annual Meeting of the American Association for Cancer Research (AACR), Los Angeles, CA, April 2007.