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Dr. Jeffrey Christoff

Professor of Medicinal Chemistry
Pharmaceutical & Biomedical Sciences
HPPEC 267
525 S. Main Street
Ada, OH 45810
419-772-2658
Biography: 


Dr. Christoff joined the faculty in the College of Pharmacy at Ohio Northern University in 1998.   He is currently Professor of Medicinal Chemistry with tenure in the Department of Pharmaceutical and Biomedical Sciences.   He serves the College as the Radiation Safety Officer and maintains a collaborative practice as an authorized nuclear pharmacist with HeartLight Pharmacy Services, Lima, Ohio.

Major curricular areas:

Medicinal Chemistry (CV, ID, CAM, CNS)
Drug Metabolism
Nuclear Pharmacy
Applied Medical Physics

Electives offered:

PHBS 5971 Independent Study - Introduction to Nuclear Pharmacy - 2 credits
BSPC 5651 Research - Nuclear Pharmacy - 2 credits

Professional Experience: 


Accreditations:

Authorized Nuclear Pharmacist, Bureau of Radiation Protection, State of Ohio, 2007
Certification in Nuclear Pharmacy, Nuclear Education Online, 2006
Ohio State Board of Pharmacy - License No.  03-1-17368, licensed by exam, 1988
 

Academic Appointments:

Professor or Associate Professor of Medicinal Chemistry, Ohio Northern University, 1998-present, Associate Professor or Assistant Professor of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, 1993-1998
American Foundation for Pharmaceutical Education Fellow, The Ohio State University, 1991-1993
University Fellow, Graduate Research Associate, or Graduate Teaching Assistant, The Ohio State University, 1988-1991

Pharmacy Practice Positions:

Nuclear Pharmacist, Collaborative Practice Agreement, HeartLight Pharmacy Services, Lima, OH, 2007–current

Relief Pharmacist, Walgreens, Phar-Mor, Stallkamp Drugs, Pharmstaff, Inc, West Central Ohio locations, 2001-2007

Staff Pharmacist, Grant Medical Center, Columbus, OH, 1988-1993

Pharmacy Intern, St. Clair Memorial Hospital, Pittsburgh, PA, 1985-1988

Pharmacy Intern, Thrift Drug Company, Washington, PA, 1984-1985

 

Consulting Positions:

Consultant/Visiting Instructor, Duquesne University, Weekend Doctor of Pharmacy Program, Medicinal Chemistry, 2005-2006
 

Pharmaceutical Industry Positions:

Research Intensive Intern, Merck, Sharp & Dohme Research Laboratories, West Point, PA, 1988
 

Professional Affiliations:

American Pharmacists Association
American Association of Colleges of Pharmacy
American Chemical Society, Medicinal Chemistry Division

 

Education: 


Ph.D. Medicinal Chemistry and Pharmacognosy, The Ohio State University, 1993

BS Pharmacy, Duquesne University, 1988

Awards: 


Kathy Karas Innovations in Teaching Award, College of Pharmacy, Ohio Northern University, 2011

Alumni Chair, College of Pharmacy, Ohio Northern University, 2008-09

Sabbatical Leave, Ohio Northern University, Winter 2006-07

Tenure, Ohio Northern University, 2002

Tenure, Midwestern University, 1998

Research Interests: 


Beyond Use Expiration Dating Studies of Tc-99m radiopharmaceuticals, Mo-99/Tc-99m Generators, and nuclear medicine adjuvant preparations

Selected Publications: 


Weatherman, K. D., Augustine, S., Christoff, J., Galbraith, W. Assessing the Stability of Common Radiopharmaceuticals Compounded and Utilized Outside Package Insert Guidelines. Int. J. Pharm. Compound., 2013, 17(3), 238-246.

Weatherman, K. D., Augustine, S., Christoff, J., Galbraith, W. Establishing Benchmark Rates of Microbial and Bacterial Endotoxin Contamination for Radiopharmaceuticals Compounded in Commercial Nuclear Pharmacy Settings. Int. J. Pharm. Compound., 2013, 17(2), 168-174.

Faulkner, T.P., Christoff, J.J., Sweeney, M.A., Oliver, N.  Pilot Study of a Distance-Learning Methodology Used on Campus for First Professional Degree Pharmacy Students in an Integrated Therapeutics Module.  Am. J. Pharm. Ed.,2005, 69(1), Article 7.

Aouad, J., Christoff, J.J. Progress Toward the Synthesis of 6-Substituted Imidazo[2,1-b]thiazoles related to Levamisole. Ohio J. Sci., 2000, 100(1), A-14.

Sprague, J.E.; Christoff, J.; Allison, J.; Kisor, D.; Sullivan, D. Development and Implementation of an Integrated Cardiovascular Module in a Pharm.D. Curriculum., Am. J. Pharm. Ed., 2000, 64(1), 20-26.  Corrigendum, Am. J. Pharm. Ed., 2000, 64(2), 220.

Christoff, J.J.; Bradley, L.; Miller, D.D.; Lei, L.; Rodriguez, F.; Fraundorfer, P.; Romstedt, K.; Shams, G.; Feller, D.R. Synthesis and Evaluation of Trimetoquinol (TMQ) Derivatives: Novel Thromboxane A2/Prostaglandin H2 (TP) Antagonists with Diminished b‑Adrenergic Agonist Activity. J. Med. Chem.1997, 40(1), 85-91.

Currie, B.L.; Chapman, R.L.; Christoff, J.J.; Sikorski, L. Patient‑Related Case Studies in Medicinal Chemistry. Am. J. Pharm. Educ., 1994, 58, 446-450.

Miller, D.D.; Christoff, J.J.; De Los Angeles, J.; Nikulin, V.; Konkar, A.; Mehta, R.; Fraundorfer, P.F.; Feller, D.R. Sites of Interaction of Trimetoquinol and Related Analogs with ß-Adrenergic Receptors. Pharmaceut.Res.1994, 11(10), S123.

Katdare, A.V.; Keller, K.O.; Christoff, J.J.; Bavitz, J.F. Evaluation of Dissolution Characteristics of an Encapsulated Water Soluble Tablet Granulation. Drug Dev.Ind. Pharm.1990, 16(7), 1109-1119.

Book Chapters

Diagnostic Imaging Agents, Wilson and Gisvold’s Textbook of Organic, Medicinal, and Pharmaceutical Chemistry, 12th edition, J. H. Block, J.M. Beale, Jr., Eds. Lippincott, Williams & Wilkins, 2010.

Currie, B.L.; Roche, V.F.; Zito, S.W. Medicinal Chemistry Case Study Workbook, Williams & Wilkins, Baltimore, MD, 1995, contributing author or co-author for cases #46, #52, #53, #61, #75, #78, #84, #102, #103, #105, #118, #119, #120, and #154.

Currie, B.L.; Roche, V.F.; Zito, S.W. Medicinal Chemistry Case Study Workbook: Instructor’s Manual, Williams & Wilkins, Baltimore, MD, 1995, contributing author or co-author for cases and/or solutions #46, #52, #53, #61, #75, #78, #84, #102, #103, #105, #118, #119, #120, #154, #213, and #223.

Multi-media Publications:

Weatherman, K. D., Augustine, S., Christoff, J. J., Galbraith, W. Stability of Radiopharmaceuticals Compounded Outside Package Insert Guidelines.  United Pharmacy Partners, Incorporated, 2011.

Weatherman, K. D., Augustine, S., Christoff, J. J., Galbraith, W. Assessing the Stability of Common Radiopharmaceuticals Compounded and Utilized outside package insert guidelines.  United Pharmacy Partners, Incorporated, 2011.

Dissertation:

Christoff, J.J. Ph.D. Thesis, The Ohio State University, Dec. 1993.  Part 1: Synthesis of Arylalkylguanidines as Dopamine Agonists.  Part 2, Section A: Modifications of Trimetoquinol and the Effects on b-Adrenergic and Thromboxane A2 Receptor Systems.  Section B: Approaches to the Asymmetric Synthesis of Irreversibly Binding Iodinated Derivatives of Trimetoquinol.