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Efforts toward the Synthesis of Levamisole

Kelli Dodson
Ohio Northern University

Levamisole, a powerful antihelmintic for lung and intestinal worms in both humans and animals is thought to possess immunostimulatory effects specifically beneficial to patients with colorectal cancer. It has been hypothesized that levamisole can be derivatized to increase its affinity for the binding pocket of thymidylate synthase and thus be a more active treatment against the DNA repair mechanism of harmful cancer cells. A synthetic route toward the synthesis of para-nitrolevamisole has been explored and further efforts to reduce the nitro group via two very different mechanisms to form the amino-derivative of levamisole have been conducted, and the results from the syntheses will be reported.

ONU Student Research Colloquium