Skip To Main Content

Dr. Phillip Zoladz

Associate Professor of Psychology
Psychology, Sociology & Criminal Justice
Hill Memorial 013
525 S. Main St.
Ada, OH 45810
(419) 772-2142
Fax: 
(419) 772-2746
Biography: 

Students in my research laboratories conduct studies on humans and rodents that focus on understanding the neurobehavioral consequences of stress, with a primary focus of using the outcomes to better understand the mechanisms underlying the development of post-traumatic stress disorder (PTSD). Currently, in my human laboratory, we are studying how genetic polymorphisms and physiological responses to stress predict which individuals are more susceptible to the effects of stress on learning and memory. In my rodent laboratory, we are examining the influences of an animal model of PTSD on cardiovascular susceptibility to ischemic injury and neurobehavioral responsivity to drugs of addiction. 

 

CURRICULUM VITAE

 

Education: 
  • - Ph.D., Behavioral Neuroscience, University of South Florida
  • - M.A., Behavioral Neuroscience, University of South Florida
  • - B.A., Psychology, Wheeling Jesuit University

 

Teaching Interests: 
  • Introduction to Psychology
  • Experimental Psychology
  • Learning & Behavior
  • Motivation & Emotion
  • Physiological Psychology
  • Psychopharmacology
  • Sensation & Perception
  • The Stressed Brain
  • Myths, Mischief & Pitfalls in Modern Science
  • Post-Traumatic Stress Disorder
  • Behavioral Genetics

 

Awards: 


R15HL132322, NHLBI
Impact of an animal model of posttraumatic stress disorder on the ischemic heart
12/2016-11/2019
Role: co-investigator
Total Direct and Indirect Costs = $411,453

R15MH104836, NIMH
Time-dependent effects of stress on learning: Physiological and genetic associations
5/2015-4/2018
Role: PI
Total Direct and Indirect Costs = $423,776

 

Research Interests: 
  • Animal models of post-traumatic stress disorder
  • Neurobiology of learning and memory
  • Effects of stress on learning and memory
  • Trauma-induced changes in brain and behavior

 

Selected Publications: 

 

BOOK CHAPTERS (* denotes supervised undergraduate student):

Zoladz, P.R. & Diamond, D.M. (2016). Psychosocial stress in rats: An animal model of PTSD based on clinically relevant risk factors. In C.R. Martin, V.R. Preedy, & V.B. Patel (Eds.), Comprehensive guide to post-traumatic stress disorder (pp. 1531-1551). New York, NY: Springer.

Zoladz, P.R. & Diamond, D.M. (2016). Psychosocial predator stress model of PTSD based on clinically relevant risk factors for trauma-induced psychopathology. In J.D. Bremner (Ed.), Post-traumatic stress disorder: From neurobiology to treatment (pp. 125-142). Malden, MA: Wiley-Blackwell.

Zoladz, P.R., Kalchik, A.E.*, Cadle, C.E.*, & Lyle, S.M.* (2014). Amygdala-induced modulation of cognitive brain structures underlies stress-induced alterations of learning and memory: Importance of stressor timing and sex differences. In A. Costa & E. Villalba (Ed.), Horizons in neuroscience research (Vol. 14) (pp. 1-40). Hauppauge, NY: Nova Science Publishers.

Zoladz, P.R., Park, C.R., & Diamond, D.M. (2011). Neurobiological basis of the complex effect of stress on memory and synaptic plasticity. In C.D. Conrad (Ed.), Handbook on stress: Neuropsychological effects of stress on the brain (pp. 157-178). Malden, MA: Wiley-Blackwell.


PEER-REVIEWED JOURNAL PUBLICATIONS (* denotes supervised undergraduate student):

Zoladz, P.R., Cadle, C.E.*, Dailey, A.M.*, Fiely, M.K.*, Peters, D.M.*, Nagle, H.E.*, Mosley, B.E.*, Scharf, A.R.*, Brown, C.M.*, Duffy, T.J.*, Earley, M.B.*, Rorabaugh, B.R., & Payment, K.P. (2017). Blunted cortisol response to acute pre-learning stress prevents misinformation effect in a forced confabulation paradigm. Hormones and Behavior93, 1-8.

Zoladz, P.R., Dailey, A.M.*, Nagle, H.E.*, Fiely, M.K.*, Mosley, B.E.*, Brown, C.M.*, Duffy, T.J.*, Scharf, A.R.*, Earley, M.B.*, & Rorabaugh, B.R. (2017). FKBP5 polymorphisms influence pre-learning stress-induced alterations of learning and memory. European Journal of Neuroscience45, 648-659.

Zoladz, P.R., Dailey, A.M.*, Nagle, H.E.*, Fiely, M.K.*, Mosley, B.E.*, Brown, C.M.*, Duffy, T.J.*, Scharf, A.R.*, Earley, M.B.*, & Rorabaugh, B.R. (2017). ADRA2B deletion variant influences time-dependent effects of pre-learning stress on long-term memory. Neurobiology of Learning and Memory140, 71-81.

Zoladz, P.R., & Diamond, D.M. (2016). Predator-based psychosocial stress animal model of PTSD: Progress toward understanding how traumatic stress generates psychopathology. Experimental Neurology284, 211-219.

Halonen, J.D., Zoladz, P.R., Park, C.R., & Diamond, D.M. (2016). Behavioral and neurobiological assessments of predator-based fear conditioning and extinction. Journal of Behavioral and Brain Science6, 337-356.

Eisenmann, E.D.*, Rorabaugh, B.R., & Zoladz, P.R. (2016). Acute stress decreases but chronic stress increases myocardial sensitivity to ischemic injury in rodents. Frontiers in Psychiatry7, 71.

Diamond, D.M., & Zoladz, P.R. (2016). Dysfunctional or hyperfunctional? The amygdala is the bull in the evolutionary China shop. Journal of Neuroscience Research, 94, 437-444.

Zoladz, P.R., Krivenko, A.*, Eisenmann, E.D.*, Bui, A.D., Seeley, S., Fry, M.E.*, Johnson, B.L.*, & Rorabaugh, B.R. (2016). Sex-dependent effects of sleep deprivation on myocardial sensitivity to ischemic injury. Stress, 19, 264-268.

Rorabaugh, B.R., Seeley, S., Bui, A.D., Krivenko, A.*, Eisenmann, E.D.*, Fry, M.E.*, Lawson, J.D.*, Stoner, L.E.*, Johnson, B.L.*, & Zoladz, P.R. (2015). Sex-dependent effects of chronic psychosocial stress on myocardial sensitivity to ischemic injury. Stress18, 645-653.

Zoladz, P.R., Peters, D.M.*, Cadle, C.E.*, Kalchik, A.E.*, Aufdenkampe, R.L.*, Dailey, A.M.*, Brown, C.M.*, Scharf, A.R.*, Earley, M.B.*, Knippen, C.L.*, & Rorabaugh, B.R. (2015). Post-learning stress enhances long-term memory and differentially influences memory in females depending on menstrual stage. Acta Psychologica160, 127-133.

Cadle, C.E.*, & Zoladz, P.R. (2015). Stress time-dependently influences the acquisition and retrieval of unrelated information by producing a memory of its own. Frontiers in Psychology6, 910.

Zoladz, P.R., Park, C.R., Fleshner, M., & Diamond, D.M. (2015). Psychosocial predator-based animal model of PTSD produces physiological and behavioral sequelae and a traumatic memory 4 months following stress onset. Physiology & Behavior147, 183-192.

Zoladz, P.R., Kalchik, A.E.*, Hoffman, M.M.*, Aufdenkampe, R.L.*, Lyle, S.M.*, Peters, D.M.*, Brown, C.M.*, Cadle, C.E.*, Scharf, A.R.*, Dailey, A.M.*, Wolters, N.E., Talbot, J.N., & Rorabaugh, B.R. (2014). ADRA2B deletion variant selectively predicts stress-induced enhancement of long-term memory in females. Psychoneuroendocrinology48, 111-122.

Zoladz, P.R., Peters, D.M.*, Kalchik, A.E.*, Hoffman, M.M.*, Aufdenkampe, R.L.*, Woelke, S.A.*, Wolters, N.E., & Talbot, J.N. (2014). Stress administered immediately before learning reduces false memory production and selectively enhances true memory in females. Physiology & Behavior, 128, 270-276. 

Zoladz, P.R., Kalchik, A.E.*, Hoffman, M.M.*, Aufdenkampe, R.L.*, Burke, H.M.*, Woelke, S.A.*, Pisansky, J.M.*, & Talbot, J.N. (2014). Brief, pre-retrieval stress differentially influences long-term memory depending on sex and corticosteroid response. Brain and Cognition85, 277-285.

Zoladz, P.R., Burke, H.M.*, Robinson, C.M.*, Woelke, S.A., Wentz, B.*, Pisansky, J.M.*, McKay, J.*, Dexter, K.W.*, & Talbot, J.N. (2013). Blunted corticosterone response to acute predator stress results in long-term spatial memory impairment. SOJ Psychology1, 7.

Burke, H.M.*, Robinson, C.M.*, Wentz, B.*, McKay, J.*, Dexter, K.W.*, Pisansky, J.M.*, Talbot, J.N., & Zoladz, P.R. (2013). Sex-specific impairment of spatial memory in rats following a reminder of predator stress. Stress16, 469-476.

Zoladz, P.R. & Diamond, D.M. (2013). Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literature. Neuroscience and Biobehavioral Reviews37, 860-895.

Zoladz, P.R., Fleshner, M., & Diamond, D.M. (2013). Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 44, 1-16.

Zoladz, P.R., Warnecke, A.J.*, Woelke, S.A.*, Burke, H.M.*, Frigo, R.M.*, Pisansky, J.M.*, Lyle, S.M.*, Talbot, J.N. (2013). Pre-learning stress that is temporally removed from acquisition exerts sex-specific effects on long-term memory. Neurobiology of Learning and Memory, 100, 77-87.

Zoladz, P.R., Fleshner, M., & Diamond, D.M. (2012). Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities. Psychoneuroendocrinology, 37, 1531-1545.

Zoladz, P.R., Park, C.R., Halonen, J.D., Salim, S., Alzoubi, K.H., Srivareerat, M., Fleshner, M., Alkadhi, K.A., & Diamond, D.M. (2012). Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex and amygdala in response to spatial learning and predator stress-induced amnesia. Hippocampus, 22, 577-589.

Zoladz, P.R. (2011). Post-traumatic stress disorder: A case for subtype identification. Ohio Psychologist, 58, 34-37.

Van Elzakker, M.B., Zoladz, P.R., Thompson, V.M., Park, C.R., Halonen, J.D., Spencer, R.L., & Diamond, D.M. (2011). Influence of pre-training predator stress on the expression of c-fos mRNA in the hippocampus, amygdala and striatum following long-term spatial memory retrieval. Frontiers in Behavioral Neuroscience, 5, 1-13.

Roth, T.L., Zoladz, P.R., Sweatt, J.D., & Diamond, D.M. (2011). Epigenetic modification of hippocampal BDNF DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of Psychiatric Research, 45, 919-926.

Zoladz , P.R., Clark, B.*, Warnecke, A.*, Smith, L.*, Tabar, J.*, & Talbot, J.N. (2011). Pre-learning stress differentially affects long-term memory for emotional words, depending on temporal proximity to the learning experience. Physiology & Behavior, 103, 467-476.

Zoladz, P.R. Muñoz, C., & Diamond, D.M. (2010). Beneficial effects of tianeptine on hippocampus-dependent long-term memory and stress-induced alterations of brain structure and function. Pharmaceuticals, 3, 3143-3166.

Zoladz, P.R. & Diamond, D.M. (2010). Use of an animal model of post-traumatic stress disorder in the study of pharmacotherapy for anxiety disorders. Culture Psy Neurosciences, 15, 6-7.

Zoladz, P.R., Woodson, J.C., Haynes, V.F., & Diamond, D.M. (2010). Activation of a remote (one-year old) emotional memory interferes with the retrieval of a newly formed hippocampus-dependent memory in rats. Stress: The International Journal on the Biology of Stress, 13, 36-52.

Zoladz, P.R. & Diamond, D.M. (2009). Linear and non-linear dose-response functions reveal a hormetic relationship between stress and learning. Dose-Response, 7, 132-148.

Conboy, L., Tanrikut, C., Zoladz, P.R., Campbell, A.M., Park, C.R., Gabriel, C., Mocaer, E., Sandi, C., & Diamond, D.M. (2009). The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats. The International Journal of Neuropsychopharmacology, 12, 329-341.

Zoladz, P.R., Park, C.R., Muñoz, C., Fleshner, M., & Diamond, D.M. (2008). Tianeptine: An antidepressant with memory-protective properties. Current Neuropharmacology, 6, 311-321.

Zoladz, P.R. & Diamond, D.M. (2008). Hormetic and non-hormetic dose-response functions in stress effects on memory and synaptic plasticity: Issues and mechanisms. American Journal of Pharmacology and Toxicology, 3, 108-121.

Zoladz, P.R., Conrad, C.D., Fleshner, M., & Diamond, D.M. (2008). Acute episodes of predator exposure in conjunction with chronic social instability as an animal model of post-traumatic stress disorder. Stress: The International Journal on the Biology of Stress, 11, 259-281.

Park, C.R., Zoladz, P.R., Conrad, C.D., Fleshner, M., & Diamond, D.M. (2008). Acute predator stress impairs the consolidation and retrieval of hippocampus-dependent memory in male and female rats. Learning and Memory, 15, 271-280.

Campbell, A.M., Park, C.R., Zoladz, P.R., Muñoz, C., Fleshner, M., & Diamond, D.M. (2008). Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress. European Neuropsychopharmacology, 18, 87-98.

Diamond, D.M., Campbell, A.M., Park, C.R., Halonen, J., & Zoladz, P.R. (2007). The temporal dynamics model of emotional memory processing: A synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson Law. Neural Plasticity, 2007, Article 60803.

Zoladz, P.R., Campbell, A.M., Park, C.R., Danysz, W., & Diamond. D.M. (2006). Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane. Pharmacology, Biochemistry and Behavior, 85, 298-306.

Zoladz, P. & Raudenbush, B. (2005). Cognitive enhancement through stimulation of the chemical senses. North American Journal of Psychology, 7, 125-140.

Raudenbush, B., Koon, J., Smith, J., & Zoladz, P. (2003). Effects of odorant administration on objective and subjective measures of sleep quality, post-sleep mood and cognitive functioning, and alertness. North American Journal of Psychology, 5, 181-192.

 

CURRENT UNDERGRADUATE RESEARCH ASSISTANTS:

Human Research

  • Tessa Duffy (Spring '15 - present)
  • Julie Handel (Fall '15-present)
  • Jen Hipskind (Fall '15-present)
  • MacKenzie Kaschalk (Fall '16-present)
  • Katelyn Keckler (Fall '16-present)
  • Brianne Mosley (Spring '15 - present) - Head Research Assistant for Human Research
  • Mackenzie Riggenbach (Fall '15-present)
  • Jordan Weiser (Fall '16-present)
  • Leighton Wireman (Fall '15-present)

Rodent Research

  • Alanis Allison (Fall '16-present)
  • Paul D'Alessio (Fall '15-present)
  • Cassandra Goodman (Fall '16-present)
  • Brooke Hertenstein (Fall '15-present)
  • Maddy Huntley (Spring '15 - present)
  • Charis Kasler (Fall '16-present)
  • Kasey Mucher (Fall '15-present)
  • Connor Ney (Fall '15-present)
  • Kiera Robinson (Fall '15-present) - Head Research Assistant for Rodent Research
  • Austen Rush (Fall '16-present)

 

Psychology, Sociology, and Criminal Justice

Robert Carrothers

419-772-2135
r-carrothers@onu.edu
Hill 018
525 South Main Street
Ada, Ohio 45810
Monday: 8 a.m.-4 p.m.
Tuesday: 8 a.m.-4 p.m.
Wednesday: 8 a.m.-4 p.m.
Thursday: 8 a.m.-4 p.m.
Friday: 8 a.m.-4 p.m.
Saturday: Closed
Sunday: Closed