2002-2004 Postdoctoral Research Fellowship, Department of Molecular Cardiology, Lerner Research Institute Cleveland Clinic Foundation
2004 – 2010 Assistant Professor of Pharmacology and Cell Biology, Ohio Northern University College of Pharmacy
2010 – present Associate Professor of Pharmacology and Cell Biology, Ohio Northern University College of Pharmacy
1995 B.S., Biology, Mount Vernon Nazarene University
1997 M.S., Biology, Bowling Green State University
2002 Ph.D., Pharmacology, Creighton University
Cell Biology / Signal Transduction
2010-2014 RO1: Project Title: Physiological functions of G-alpha-i/o and control by regulators of G protein signaling. National Institute of General Medical Sciences.
2010 Project Title: Regulator of G protein signaling proteins modulate protection from ischemic injury in the mouse heart. Bower, Bennett, and Bennett Endowed Research Award, Ohio Northern University.
Role: Principal Investigator.
G protein-coupled receptors.
Regulator of G protein Signaling (RGS) proteins
Cardiac ischemia / reperfusion injury
Waterson R, Thompson C, Mabe N, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR (2011) Gαi2-mediated protection from ischemic injury is modulated by endogenous RGS proteins in the mouse heart. Cardiovascular Research 91:45-52.
Doze V, Handel EM, Jensen KA, Darsie B, Luger EJ, Haselton JR, Talbot JN, Rorabaugh BR. (2009) α1A-and α1B adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. Brain Research 1285:148-157.
Rorabaugh BR, Gaivin RJ, Papay RS, Shi T, Simpson PC, Perez DM. (2005) Both a1A- and a1B-adrenergic receptors cross-talk to downregulate b1-adrenergic receptors in mouse heart: coupling to differential pertussis toxin-sensitive pathways. Journal of Molecular and Cellular Cardiology 39:777-784.
Rorabaugh BR, Ross SA, Gaivin RJ, Papay RS, McCune DF, Simpson PC, Perez DM. (2005) a1A- but not a1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism. Cardiovascular Research 65:436-445.
Gonzalez-Cabrera PJ, Shi T, Yun J, McCune DF, Rorabaugh BR, Perez DM. (2004) Differential regulation of the cell cycle by a1-adrenergic receptor subtypes. Endocrinology 145:5157-5167.
McCune DF, Gaivin RJ, Rorabaugh BR, Perez DM. (2004) Bulk is a Determinant of Oxymetazoline affinity for the alpha1A‑adrenergic receptor. Receptors and Channels 10:109-116.
Papay R, Gaivin R, McCune DF, Rorabaugh BR, Macklin WB, McGrath JC, Perez DM. (2004) The a1B-adrenergic receptor is expressed in neurons and NG2 oligodendrocytes. Journal of Comparative Neurology 478:1-10.
Recent Published Abstracts:
Mabe N, Seeley S, Fehrman L, Garber P, Neubig RR, Rorabaugh BR (2013) RGS 2 and RGS 4 Differentially Modulate G Protein Coupled Receptor Signaling in the Mouse Aorta. FASEB Journal 27:1095.3.
Amos ME, Binkey AE, Taylor P, Rorabaugh BR, Neubig RR, Traynor JR, Talbot JT (2011). RGS4 as a regulator of the antidepressant effects of SSRIs. FASEB Journal 26:1045.6
Mabe, N, Thompson CG, Waterson RE, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR (2011) Inhibition of Gαi2-RGS protein interactions protects the heart from ischemic injury. FASEB Journal 25:1085.3.
Waterson R, Mabe N, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR (2010) Gαi2- Mediated Protection from Ischemic Injury is Modulated by Regulator of G Protein Signaling Proteins. Circulation 122:A18673.