BSPC 543: CNS Module
August 2008-Present
Assistant Professor, Pharmacology
Department of Pharmaceutical Sciences, Raabe College of Pharmacy, Ohio Northern University
June 2003-August 2008
Assistant Professor, Pharmacology
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Butler University, IN
January 2001-May 2003
Postdoctoral Research Assistant
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University School of Pharmacy, West Lafayette, IN; Advisor: Eric L. Barker, Ph.D.
Projects:
Examined the effects of CB1 cannabinoid and D2 dopamine receptor activation on endocannabinoid transport.
Cloning of a novel transporter protein for the endogenous cannabinoid anandamide in mammalian cells.
June 1994-December 2000
Doctoral Student
Advisor: Cecilia J. Hillard, Ph.D.
Dissertation: Characterization of an N- arachidonlyethanolamine (anandamide) transport process in cerebellar neurons.
August 1991-May 1994
Master’s Student
Advisor: A. Stephen Dahms, Ph.D.
Investigated the activity of Mg 2+ ATPase in chicken gizzards and its role in smooth muscle contraction.
October 1986- May 1991
Student Assistant
Science Stockroom, California State University, Bakersfield, CA.
June 1998-January 2001
Doctor of Philosophy (Ph.D.)
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
August 1994-May 1998
Master of Science (M.S.)
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
August 1991-May 1994
Master of Arts (M.A.)
Department of Chemistry, San Diego State University, San Diego, CA
September 1986-May 1991
Bachelor of Science (B.S.)
Department of Chemistry, California State University, Bakersfield, CA
RESEARCH EXPERIENCE
Using Expression Cloning and Fluorescence Activated Cell Sorting (FACS) to Identify the Putative Carrier for Anandamide
Starting/ending dates: 6/01/06 to 5/31/07
Does the Transport of N-arachidonylethanolamine Across the Neutrophil Plasma Membrane Require a Carrier Protein?
Starting/ending dates: 12/15/05 to 12/15/06
Instructional Development Grant - Introduction to Principles of Drug Action
Starting/ending dates: 6/01/05 to 9/30/05
Status: Funded
Instructional Technology Grant–Redesign of Introduction to Principles of Drug Action Course (RX318) Incorporating Pharmacology Simulation Delivered by Tablet PCs
Starting/ending dates: May 2005 to June 2006
Molecular Identification of a Novel Carrier Protein for the Endogenous Cannabinoid, Anandamide
Starting/ending dates: 6/01/04 to 5/31/05
Making Novel Plasmids to Enable Molecular Identification of a Carrier Protein for the Endogenous Cannabinoid, Anandamide
Starting/ending dates: 5/17/04 to 7/16/04
Molecular Identification of a Novel Carrier Protein for the Endogenous Cannabinoid, N-Arachidonylethanolamine
Starting/ending dates: 10 week period, Summer 2004
Status: Not Funded
(b) Peer-Reviewed Publications
Rademacher, D.J., Meier S.E., , Shi L, Ho W.-S.V, Jarrahian A., and Hillard C.J. (2008) Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology 54, 108-116.
- Hillard C.J. and Jarrahian A. (2005) Accumulation of anandamide: Evidence for cellular diversity. Neuropharmacology 48, 1072-1078.
- Jarrahian A., Watts V.J., and Barker E.L. (2004) D2 dopamine receptors modulate Gα-subunit coupling of the CB1 cannabinoid receptor. J. Pharmacol. Exp. Ther. 308, 880-886.
- Hillard C.J. and Jarrahian A. (2003) Cellular accumulation of anandamide: consensus and controversy. Br. J. Pharmacol. 140(5): 802-808.
- Bisogno T., MacCarrone M., De Petrocellis L., Jarrahian A., Finazzi-Agro A., Hillard C., and DiMarzo V. (2001) The uptake by cells of 2-arachidonylglycerol, an endogenous agonist of cannabinoid receptors. Eur. J. Biochem. 268(7), 1982-1989.
- Hillard C.J. and Jarrahian A. (2000) The movement of N-arachidonylethanolamine (anandamide) across cellular membranes. Chem. Phys. Lipids 108, 123-134.
- Jarrahian A., Manna S., Edgemond W.S., Campbell W.B., and Hillard C.J (2000). Structure-activity relationships among N-arachidonylethanolamine (anandamide) head group analogues for the anandamide transporter. J. Neurochem. 74, 2597-2606.
- Hillard C.J., Edgemond W.S., Jarrahian A., and Campbell W.B. (1997). Accumulation of N-arachidonylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J. Neurochem. 69, 631-638.
- Jarrahian A. and Hillard C.J. (1997) Arachidonylethanolamine (anandamide) binds with low affinity to the dihydropyridine binding sites in brain membranes. Prosta. Leuko. Ess. Fatty Acids. 57 (6), 551-554.
(c) Abstracts
Poster Presentations:
- Meier S.E., Rademacher, D.A., Jarrahian A., Shi L, Ho W.S.V, and Hillard C.J. Restraint stress affects amygdalar, ventral striatal, and medial prefrontal cortical endocannabinoid contents in mice. Society for Neuroscience, Atlanta, GA, October 14-18, 2006.
- Jarrahian A., and Barker E.L. Differential regulation of adenylate cyclase by D2 dopamine and CB1 cannabinoid receptors. Federation of American Societies of Experimental Biology, San Diego, CA, April 11-16, 2003.
- Jarrahian A., Rakhshan F., and Barker E.L. Regulation of the uptake of the endogenous cannabinoid anandamide by cyclic AMP. Society for Neuroscience, San Diego, CA, November 10-15, 2001.
- Muthian S.K.G., Jarrahian A., Manna A., Greenberg M., Nithiptikom K., Campbell W.B., and Hillard C.J. Structure-activity relationships for substrates and inhibitors of the neuronal anandamide uptake carrier. International Cannabinoid Research Society, La Grande Motte, France, July 23-25, 1998.
- Jarrahian A., Olson L.J., and Drewett J.G. Viral expression of active guanylyl cyclase-A fails to open cystic fibrosis transmembrane regulator. Fifth Annual Medical College of Wisconsin Graduate Student Poster Session, October 1996.
- Caldwell C.C., Norman V.E., Jarvis A.O., Hornyak S.C., Jarrahian A., Cunningham H.B., Kang J.J., and Dahms A.S. Plasma membrane ecto-ATPase: Probes of catalytic and regulatory subunits. Proceedings MBRS Symposium, Atlanta, Georgia, September 1993.
Podium Presentations:
- Jarrahian A., Campbell W.B., and Hillard C.J. Evidence for a protein-mediated carrier in cerebellar granule cells. International Cannabinoid Research Society, Hunt Valley, Maryland, June 22-24, 2000.
- Jarrahian A., Campbell W.B., and Hillard C.J. Studies of N-arachidonylethanolamine (anandamide) efflux from cerebellar granule cells. International Cannabinoid Research Society, Atlanta, Georgia, June 19-22, 1997.
